Intraoperative Circulation Phenotyping to Guide Vasoactive Medication in Kidney Transplant Recipients
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 255
- 试验地点
- 1
研究概览
简要总结
The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels. Researchers will compare the results of vasopressin to those who received calcium chloride.
详细描述
This prospective, single-arm interventional study evaluates a phenotype-guided vasoactive protocol during adult kidney transplantation. Intraoperative monitoring includes pulse contour analysis and repeated FPC testing. Based on predefined phenotype criteria, vasoactive support is assigned as follows: vasopressin infusion for Hyperdynamic physiology, norepinephrine infusion for Mixed Physiology, calcium chloride boluses and/or low-dose dopamine infusion for Poor Contractility, and fluid-guided management for Normal physiology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or older
- •Undergoing kidney transplantation at Cedars-Sinai Medical Center
- •Able to provide informed consent
排除标准
- •Patients unable to provide informed consent
- •Patients with contraindications to protocol vasoactive medications, as determined by the treating anesthesiologist
- •Patients in whom required intraoperative monitoring cannot be performed
研究者
Jennifer Cutler
PI
Cedars-Sinai Medical Center