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临床试验/NCT03879369
NCT03879369Unknown不适用

Sexual Dysfunction in Female Patients With Adult Acne Vulgaris

Assiut University0 个研究点目标入组 50 人开始时间: 2019年5月最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
主要终点
Evaluation of sexual function using FSFI questionnaire

研究概览

简要总结

Assessment of sexual dysfunction in adult females with acne vulgaris and its relation to other variables as quality of life, acne severity and hormonal dysfunction.

详细描述

Acne vulgaris is a common chronic inflammatory skin disease of pilosebaceous units. It is characterized by formation of comedones, erythematous papules, pustules and less frequently by nodules, deep pustules, or pseudocysts. In some cases, it may be accompanied by scarring. It is the most common dermatological condition affecting adolescents worldwide. It has a prevalence of almost 85% in people aged 12-24 years . Women have a high prevalence than men, especially after 25 years of age. It affects 12%-22% of women in their adult life.

Several factors are involved in the pathogenesis of the disease including abnormal sebum production, altered follicular keratinization with subsequent follicular plugging and Propionibacterium acnes colonization . Also, endocrine factor or androgens are considered a major factor involved in the pathogenesis of the disease. It probably results from an androgen excess or exacerbated response of the pilosebaceous unit to the normal circulating androgen levels.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder to affect women in their reproductive years. It is characterized by hyperandrogenism which results in a series of skin changes including hirsutism, acne, seborrhea and androgenetic alopecia.

Acne vulgaris causes profound negative psychological and social effects on the quality of life (QoL) of patients. It has a great impact on appearance which is linked with self-esteem and self-confidence. Factors that influence the psychological impact of acne include perceived sexual attractiveness, relationships with family and friends, judgments of others, stigmatization, stress, and fear of scarring.

Several researches concluded that body image is an important psychological factor in women sexual well-being. Female sexual dysfunction may associate certain dermatologic diseases as a result of its effect on self-esteem and psychological conditions.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Other

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • adult female patients with acne vulgaris between 18-40 years old

排除标准

  • any disease affecting sexual function will be excluded like
  • female genital mutilation.
  • females with other major medical, endocrine and genital comorbidities or receiving medications that affect sexual function.
  • females with frank psychological disturbances.

结局指标

主要结局

Evaluation of sexual function using FSFI questionnaire

时间窗: 30 minutes

Summation of the mean score of the six domains of the FSFI questionnaire

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Asmaa A Ghallab

principal investigator

Assiut University

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