The Interrelationship Between Vitamin D, Bone, Illness, Injury and Its Impact on Exercise Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Seasonal Change in the Number of Participants with Deficiency in Vitamin D (according to government cut-off points in the UK and USA) in University Athletes and their Healthy Controls.
研究概览
简要总结
Athletes and active individuals have been identified as an at-risk group for a low vitamin D status, specifically those residing in countries of higher latitude (such as the United Kingdom). This especially applies to those who train indoors for their sport, this is because Vitamin D is primarily produced following skin exposure to ultraviolet B (UVB) exposure. Vitamin D is essential for the maintenance of optimal bone and musculoskeletal health. It has also been suggested to play a role in the prevention of illness incidence, such as in upper respiratory tract infections (URTI). More recent research has indicated that an improved Vitamin D status may also play a role in enhancing exercise performance. Therefore, having a poor vitamin D status could negatively impact athletic training and competition. The purpose of this study is to evaluate the prevalence of vitamin D deficiency in university athletes and inactive controls in spring and autumn.
During this study the subjects will be asked to visit the labs on two occasions, at the beginning of the study for baseline measurements, and again on two occasions at the end of the study. Participants will have the following outcomes assessed: Sport performance (vertical jump height, muscular strength and aerobic fitness), peripheral Quantitative Computed Tomography (pQCT) scan of the bone mineral composition of the tibia, total body composition via Dual Energy X-ray Absorptiometry (DEXA),total and hip/femoral head bone mineral density and content to assess fracture risk via DEXA. Serum 25(OH)D levels (≈15ml of whole blood will be collected for these measurements. Dietary intake using self-reported food diaries. In addition illness and injury incidence will be recorded daily throughout the study in a booklet provided to the participants.Throughout the trial, the participants will be contacted via telephone/ email on a monthly basis to discuss any issues and maintain good communication.
详细描述
During this study the subjects will be asked to visit the labs on 4 different occasions. There will be two occasions, at the beginning of the study for baseline measurements, and again on two occasions at the end of the study.
Data collection will take place across two testing sessions (separated by ~24 - 72 hrs) in the Autumn and Spring period.
Session 1
- Peripheral Quantitative Computed Tomography (pQCT) scan of the bone mineral composition of the tibia.
- Total and percentage lean and fat mass and total bone mineral density via Dual Energy X-ray Absorptiometry (DEXA).
- Sport performance: Vertical jump height and maximal oxygen uptake (VO2 max) test.
Session 2
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •University athlete inclusion criteria:
- •Male or female
- •Aged 18-30
- •Regularly train/compete for Team Surrey Basketball, Boat Club, Swimming and Waterpolo, Netball or Rugby (for more than 4 hours/week)
- •In good physical health
- •Have a BMI >18 kg/m2
- •Able to provide written informed consent
- •Control group inclusion criteria:
- •Male or Female
- •Age 18-30
- •Do not use sun beds/ will not be going on a sun holiday/ returning home to a traditional sun holiday location between February 2017 and October
- •This is because the results will be used to represent the Vitamin D status of young sporting individuals residing within the UK during these seasons.
- •Do not take supplements containing Vitamin D
- •Do not compete for Team Surrey and exercise less than 150 minutes / week.
- •BMI: 18 - 30 kg/m2
排除标准
- •Currently receiving treatment for medical conditions that are likely to affect vitamin D metabolism
- •Hypercalcaemia (>2.5mmol/L)
- •Regular use of sun-beds
- •Having a sun holiday one month prior to commencing the study or plans for a sun holiday within the study period or will be returning home to a sun holiday location.
- •Use of vitamin supplements containing vitamin D (if the prospective participants agrees to stop Vitamin D supplementation to join the study, a wash-out period of 8 weeks prior to commencing the trial would be acceptable).
- •Excess alcohol intake for participants aged 18 years (> 21 units for males, > 14 units for females per week, as per Government guidelines)
- •Those under dietary restriction (except vegetarianism) or following a weight-reducing diet.
- •Clinically significant haematological abnormalities other than mild anaemia (Hb <12.0g/dl)
- •Active malignancy
- •Pregnant or planning a pregnancy during the study period
结局指标
主要结局
Seasonal Change in the Number of Participants with Deficiency in Vitamin D (according to government cut-off points in the UK and USA) in University Athletes and their Healthy Controls.
时间窗: 1 year
This will be assessed by measuring serum 25(OH)D levels in participants during Autumn and Spring. Vitamin D status will be measured in nmol/L
次要结局
- Seasonal Change in Bone Mineral Density in University Athletes(1 year)
- The change in vitamin D status due to participation in indoor or outdoor training in university level athletes between Autumn and Spring.(1 year)
- Changes from baseline in muscular power throughout an academic sporting season(1 year)
- Changes from baseline in muscular strength throughout an academic sporting season(1 year)
- Seasonal Change in the Incidence of Injury in University Athletes(1 year)
- Seasonal Change in Bone Mineral Content in University Athletes(1 year)
- Change between autumn and spring and the effects of high, medium and low impact sports on bone mineral density in university athletes(1 year)
- Changes from baseline in aerobic fitness throughout an academic sporting season(1 year)
- Change from baseline in the incidence of injury and illness and its correlation with vitamin D status(1 year)
研究者
Saskia Wilson-Barnes
PhD Research Fellow
University of Surrey