The Predictive Scores for Gastric Cancer in Gastric Intestinal Metaplasia (GIM) Patient: a Recommendation for Thai Population
试验速览
- 阶段
- 不适用
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- The prevalence of early gastric cancer in gastric intestinal metaplasia(GIM) patient from 5 year-follow-up in Thai population
研究概览
简要总结
The predictive scores for gastric cancer in gastric intestinal metaplasia(GIM) patient: a recommendation for Thai population.
Objective:
To evaluate major risk factors for gastric cancer in gastric intestinal metaplasia(GIM) patient in order to propose the appropriate recommendation for Thai people.
Research Design:
Single center, retrospective-cohort study.
详细描述
Study population and Sample size at Faculty of Medicine, Chulalongkorn University The patients who were diagnosed gastric intestinal metaplasia from 1997 to 2012 and then follow up for 5 years. Estimate sample size =280
- Investigational product, dosage & route of administration
- Questionnaire for explore the risk factors
- EGD with biopsy
- Blood sampling for gastro panel
- Duration of participation
- 5 years or until diagnose gastric cancer
Statistical method:
Unconditional-binary-logistic regression
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients were diagnosed GIM
- •All patients have to sign the consent form
排除标准
- •Previous gastric surgery including gastrectomy and bypass surgery
- •Bleeding tendency including decompensated cirrhosis, chronic kidney disease and long-tem antiplatelets or anticoagulants
- •HIV infection
- •History of proton pump inhibitor use within 1 week
- •History of antibiotic use within 4 weeks
结局指标
主要结局
The prevalence of early gastric cancer in gastric intestinal metaplasia(GIM) patient from 5 year-follow-up in Thai population
时间窗: Up to 5 years
In Thailand, gastric cancer patients usually presented with advance stage and carried the dismal prognosis. GIM is a well known precancerous lesion. The appropriate follow-up period in high risk GIM patient can increase the prevalence of early gastric cancer and reduce the mortality rate of gastric cancer
次要结局
未报告次要终点
研究者
Rapat Pittayanon, MD
Principle investigator
King Chulalongkorn Memorial Hospital