NCT03813082已完成不适用
Age-related Changes in Sleep-wake Regulation: Effects of Sleep Loss on Possible Molecular Markers of Sleep Need
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- Sleep-wake induced change in cerebral availability of mGluR5 (metabotropic glutamate receptors of subtype 5)
研究概览
简要总结
A sleep deprivation protocol combined with state-of-the-art, simultaneous positron emission tomography and magnetic resonance spectroscopy imaging will be employed to investigate the effects of sleep deprivation and aging on hypothesized molecular markers of sleep need.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male individuals
- •age: 20-35 or 60-70 years
- •right-handed
- •non-smokers
- •moderate caffeine/alcohol consumption
- •normal BMI
排除标准
- •Sleep/circadian rhythms disturbances
- •former brain injuries with loss of consciousness and brain anomalies
- •drug intake/consumption
- •medication intake
- •cardiac pacemaker
- •neurological disorders
- •prior participation (during past 2 years) in radiological or nuclear experiment
结局指标
主要结局
Sleep-wake induced change in cerebral availability of mGluR5 (metabotropic glutamate receptors of subtype 5)
时间窗: Change from baseline metabotropic glutamate receptors of subtype 5 availability after 33 hours of prolonged wakefulness and 8 hours of recovery sleep
Positron emission tomography
次要结局
- Sleep-wake induced change in waking electroencephalogram (EEG)(Change from baseline waking EEG during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep)
- Sleep-wake induced change in subjective state(Change from baseline sleepiness during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep)
- Sleep-wake induced change in cognitive performance(Change from baseline cognitive performance during 33 hours of prolonged wakefulness and after 8 hours of recovery sleep)
- Sleep-wake induced change in potential molecular markers of sleep need(Change from baseline microRNA, fragile X mental retardation protein and brain-derived neurotrophic factor concentrations after 33 hours of prolonged wakefulness and 8 hours of recovery sleep)
- Sleep-wake induced change in glutamate concentration in prefrontal cortex and basal ganglia(Change from baseline glutamate concentration after 33 hours of prolonged wakefulness and 8 hours of recovery sleep)
- Sleep-wake induced change in sleep electroencephalogram (EEG)(Change from all-night baseline sleep EEG in 8 hours of recovery sleep after 33 hours of prolonged wakefulness)
研究者
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