Decline of mentale functions in adults with Down Syndrome: clinical and experimental study on the effects of treatment with fluoxetine and of cognitive and physical training.

IRCCS FONDAZIONE STELLA MARIS0 个研究点开始时间: 2012年3月13日最近更新: 2014年6月10日

适应症

试验速览

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•Inclusion criteria are: 1) SD 2) subjects of both sexes and older than 30 years 3) signing of informed consent by the parent or legal tutor of the patient.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 38
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 2

•Exclusion criteria are: 1) the presence of clinical signs of dementia at the first valuation, 2) drugs that may interact with fluoxetine (Monoamine Oxidase, Phenytoin, serotonergic drugs, lithium and tryptophan, oral anticoagulants, Electroconvulsive Therapy, drugs that interact with the CYP2D6 isoenzyme system in the liver), 3) medical conditions that are contraindicated for treatment with fluoxetine (Mania, Hepatic and renal failure, diabetes, Akathisia / psychomotor restlessness, bleeding disorders, epilepsy), 4) established pregnancy (the pregnancy will be investigated in females of childbearing age through the declaration of the person and / or tutor).

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