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临床试验/NCT03281915
NCT03281915Unknown不适用

Comparison Between Impact of Inguinal and Subinguinal Approaches of Varicocelectomy on Semen Parameters in Patients With Normal Semen Analysis

Assiut University1 个研究点 分布在 1 个国家目标入组 32 人开始时间: 2017年10月15日最近更新:
适应症

试验速览

阶段
不适用
入组人数
32
试验地点
1
主要终点
Semen analysis

研究概览

简要总结

to evalute the effect inguinal and subinguinal approach of varicoceclectomy on semen parameter for patients complaining of varicocele with normal semen parameter (pain is the main complaint)

详细描述

the varicocele is defined as dilated and incompetent veins within the pampiniform plexus of spermatic cord. varicocele has been described as the most common surgically correctable cause of male subinfertility.this is a disease that devolops during puberty when both endocrine and exocrine function of the testicle dramatically increases, along with testicular blood flow. varicocele only rarely detected in boys less than 10 years. left sided varicocle found in 15% of healthy young men.incontrast, the incidence in sub fertile men approaches 40% bilateral varicocele is uncommon in healthy men (less than 10%) but palpated in 20% in sub fertile men. in-general varicocele don't spontaneously regress. an accurate physical examination remain the corner stone of varicocele diagnosis.

several anatomic features contribute to the predominance of left sided varicocele is the left intrnal spermatic vein longer than the right and it typically joins the left renal vein at a right angle.as result of this character higher venous pressures fair transmited to the left spermatic vein and result in reterograde reflux of blood.

varicocle are associated with testicular atrophhy and varicocle correction can reverse atrophy in adolececnt. there is strong evidence affect semen quality it can cause abnormalties in concentration, motility and morphology.main defect is the motility.

indication of varicocelectomy:

  1. Large varicoceles in adolescents
  2. Childhood varicocele with testicular atrophy
  3. Varicoceles with elevated FSH values, or low testosterone levels
  4. Varicoceles with scrotal pain
  5. Cosmetic indication
  6. Male infertility with pathological semen analysis and varicocele

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
19 Years 至 45 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • age more than 19 years old
  • primary varicocele

排除标准

  • secondary varicocele recurrent varicocele age less than 19 years

结局指标

主要结局

Semen analysis

时间窗: 3months

Motility morphology concentration

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Abdelrahman Mohamed Abdelkader

Resident

Assiut University

研究点 (1)

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