Comparison of Analgesia Nociception Index (ANI) guided analgesia administration with Standard Clinical Practice during Routine General Anaesthesia on post-operative pain scores and post-operative opioid requirement in patients undergoing spinal surgery

The University of Adelaide0 个研究点目标入组 60 人开始时间: 2014年2月11日最近更新: 2020年1月13日

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•Patients scheduled for non-emergent, spinal surgery, aged 18-75 years, American Society of Anesthesiologists (ASA) score 1 or 2, competent to consent to participation, able to use a Visual Analogue Scale (VAS) and able to activate a patient controlled analgesia (PCA) machine post-operatively.

•Emergency surgery
•Inability to consent, lack of written consent or speak English fluently
•Pregnancy or lactation. Pregnancy test will be performed in all women of child bearing potential
•Cardiac morbidity
•Non-regular sinus cardiac rhythym
•Cardiac disease which impacts usual daily functioning (equivalent to ASA greater than or equal to 3)
•Implanted cardiac pacemaker
•Concurrent medications with a major effect affect upon the sinus node
•Expected duration of surgery greater than 3 hours (180 minutes)
•Extremes of weight (Body Mass Index less than or equal to 19 or greater than or equal to 35 kg per meter squared)
•Pre-operative chronic opioid use or chronic pain, equivalent to oxycodone 20mg per oral, per day for more than 6 weeks
•Allergy or intolerance to any of the study drugs
•Use of neuraxial anaesthesia

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