Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 186
- 试验地点
- 1
- 主要终点
- HMGB1
研究概览
简要总结
Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 65 years scheduled for elective or emergency hip fracture surgery.
排除标准
- •Patient refusal
- •Inflammation or wound at puncture site, increased intracranial pressure, bleeding diathesis
- •Allergies to propofol or its ingredients, soybeans or peanuts
- •Patients with altered mental status
- •Illiterate patients or foreigners
研究组 & 干预措施
Group S
Spinal anesthesia with 0.5% bupivacaine
干预措施: Bupivacaine (Drug)
Group D
General anesthesia with desflurane
干预措施: Desflurane (Drug)
Group P
General anesthesia with propofol total intravenous anesthesia
干预措施: Propofol (Drug)
结局指标
主要结局
HMGB1
时间窗: from preoperative baseline to 72hours
IL-6
时间窗: from preoperative baseline to 72hours
NT-proBNP
时间窗: from preoperative baseline to 72hours
hemoglobin
时间窗: from preoperative baseline to 72hours
total lymphocyte count
时间窗: from preoperative baseline to 72hours
albumin
时间窗: from preoperative baseline to 72hours
creatinine
时间窗: from preoperative baseline to 72hours
potassium
时间窗: from preoperative baseline to 72hours
troponin-T
时间窗: from preoperative baseline to 72hours
CRP
时间窗: from preoperative baseline to 72hours
次要结局
未报告次要终点
