Prolactin and FGF21 in Gestational Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Gestational diabetes mellitus (GDM)
研究概览
简要总结
Prolactin (PRL) and PRL receptor (PRLR) signaling has been validated to play an important role in the modulation of glucolipid metabolism. However, the role of serum PRL levels in gestational diabetes mellitus (GDM) remains unclear. The investigators aimed to explore the possible influence of serum PRL within or without normal range on the development of GDM.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •aged 18 to 45 years
- •completed a 75-g oral glucose tolerance test (OGTT)
- •females with pregnancy
排除标准
- •severe liver and renal dysfunction, preexisting heart disease, malignancy, or endocrine diseases such as pituitary adenoma and hypogonadism
- •mental illness
- •genetic disease
- •current or previous treatment that might affect PRL and insulin secretion
- •diabetes before pregnancy
- •loss to follow-up, or withdrawal from the study
- •unable to understand and comply with the study protocol.
结局指标
主要结局
Gestational diabetes mellitus (GDM)
时间窗: 2019-2023
GDM is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy. It can be diagnosed by the criteria: a fasting plasma glucose (FPG) concentration of O126 mg/dl on two separate occasions or a random blood glucose concentration of O200 mg/dl on two separate occasions.
PRL
时间窗: 2019-2023
serum prolactin level
次要结局
- Insulin resistance (IR)(2019-2023)
- HOMA-IR(2019-2023)
- OGTT(2019-2023)
研究者
Shen Qu
Principle investigator
Shanghai 10th People's Hospital