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临床试验/NCT04541966
NCT04541966已完成不适用

What Happens to First Trimester Nuchal Translucency Greater Than or Equal 99ème Percentile and Inferior 3.5 mm

University Hospital, Montpellier1 个研究点 分布在 1 个国家目标入组 230 人开始时间: 2020年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
230
试验地点
1
主要终点
Pregnancies without ultrasound or genetic abnormalities

研究概览

简要总结

First trimester nuchal translucency is a call point for genetic abnormalities and birth defects. Nuchal translucency varies with LCC and therefore with gestational age as described by Chung et al who created a 99th percentile curve of nuchal translucency versus LCC. The majority of centers use the 3.5 mm cutoff as the 99th percentile instead of using nuchal translucency based on LCC. The objective of this study is to compare the fate of nuchal hyperclites> = 99th p but <3.5mm versus 3.5mm. For this the investigators have studied the ultrasound and genetic abnormalities. The investigators were also interested in the pregnancy outcomes and the percentage of pregnancies in the group> = 99th p and <3.5mm that would have been sampled for a high combined risk for trisomy 21, and therefore to determine the benefit of a systematic sample. for HCN as well as the interest of performing an ACPA that would not be performed on a sample with a high risk of trisomy 21.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

性别
Female
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Pregnancies without ultrasound or genetic abnormalities

时间窗: immediate antenatal and postnatal period

Pregnancies without ultrasound or genetic abnormalities

次要结局

  • ACPA interest(immediate antenatal and postnatal period)
  • percentage of samples for high risk combined for trisomy 21(immediate antenatal and postnatal period)
  • Pregnancy outcomes(immediate antenatal and postnatal period)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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