NCT06984510招募中不适用
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population: a Cohort Study
Ningbo No. 1 Hospital1 个研究点 分布在 1 个国家目标入组 2,720 人开始时间: 2025年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,720
- 试验地点
- 1
- 主要终点
- Incidence of onset T2DM
研究概览
简要总结
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Abdominal ultrasound data available in annual health check-up records
- •At least one of the following five metabolic indicators recorded annually:
- •(1) Body mass index (BMI) or waist circumference (2) Blood pressure (3) Serum triglycerides (4) High-density lipoprotein cholesterol (HDL-C) (5) Fasting plasma glucose or glycated hemoglobin (HbA1c)
排除标准
- •Age <20 or >90 years
- •Other causes of hepatic steatosis (e.g., alcoholic liver disease or hepatitis B infection)
- •Type 2 diabetes mellitus at baseline
- •Missing baseline data for any of the following variables: systolic blood pressure, albumin, alkaline phosphatase, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), total cholesterol, lymphocyte percentage, white blood cell count, mean corpuscular volume, uric acid, fasting plasma glucose, and red cell distribution width (RDW)
结局指标
主要结局
Incidence of onset T2DM
时间窗: through study completion, an average of 3 year
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effect of Age on Glucose and Lipid MetabolismLipid Metabolism DisordersGlucose Metabolism DisordersMetabolic DiseasesNCT01737164The University of Texas Health Science Center at San Antonio44
已完成
不适用
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?Type 2 Diabetes MellitusNCT01536808Hospices Civils de Lyon150
招募中
4 期
Effect of Sodium-glucose Cotransporter-2 Inhibitor in Cellular Senescence in Patients With Cardiovascular Diseases or Type 2 DiabetesSodium-Glucose Transporter 2 InhibitorsCellular SenescenceDiabetes MellitusNCT05975528Yonsei University92
已完成
不适用
Relationships between the duration of illness and the current status of diabetes in elderly patients with type 2 diabetes mellitustype 2 diabetes mellitusJPRN-UMIN000018591Edogawa Hospital1,436
已完成
不适用
Hypoxia and Exercise in the ElderlyElderly PersonsNCT02196623Hannover Medical School29