Variations of the Lung Compliance During Extracorporeal Circulation and Post Operative Pulmonary Complications
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- pulmonary compliance during cardiac surgery
研究概览
简要总结
the decrease in thoracopulmonary compliance after cardiac surgery is well known . The investigators hypothesize that the major factor determining pulmonary outcome after cardiac surgery is the alteration of pulmonary compliance during cardiopulmonary bypass(CBP) and that this alteration is due to CBP itself through pulmonary blood emptying.
详细描述
compliance is the compliance calculate when thorax is closed, the pulmonary compliance is the compliance calculated when thorax is opened After operation chest X-ray are daily done and blood samples as needed. Were recorded death, time of extubation,duration of non invasive ventilation,of Intensive Care Unit stay and of total hospital stay, troponin peak, lactates, blood gases, ionogram and count.Variations of compliance is analyzed through one factor paired Anova or Wilcoxon paired test. Decrease of compliance and respiratory complications are analyzed through binomial logistic regression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for standard aortic
- •mitral or coronary surgery
排除标准
- •emergency operation
- •no complete preoperative echocardiography
- •surgery needing multiple table position changes
- •unstable cardiac or respiratory condition
- •difficult patient needing multiple care and/or special attention
结局指标
主要结局
pulmonary compliance during cardiac surgery
时间窗: intraoperative
compliance is calculated by dividing tidal volume (ml) by the difference between plateau-inspiratory pressure (mmHg) and end-expiratory pressure (mmHg) before ,during and after CBP
次要结局
- thoracopulmonary compliance during cardiac surgery(intraoperative)
- pulmonary complications including death after cardiac surgery(1 month)