Seasonal Changes in Kidney Function Among Female Adults Post-Menopause
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Plasma neutrophil gelatinase-associated lipocalin (NGAL)
研究概览
简要总结
The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group. While heat stress can reduce kidney function, previous research has not accounted for physical activity, diet, hydration, or sun exposure.
详细描述
Intense heat stress on the body can reduce kidney function. A recent study reported that blood markers of kidney function are lower among people in hotter climates. However, these data did not consider physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight. Therefore, the investigators invite participants to help determine whether there are seasonal changes in kidney function biomarkers. This will also help the investigators understand if physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight affect kidney function biomarkers between seasons. The investigators are studying female adults post-menopause since they are an understudied group.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female aged ≥55 years old
- •Self Reported as at least one year post-menopause
- •Live in Tallahassee, Florida, or the surrounding area
排除标准
- •Have a BMI of ≥30 kg/m2
- •Systolic blood pressure of ≥140 and/or diastolic blood pressure ≥90 mmHg
- •Self Reported Current or recent (regular use within the past six months) use of a diuretic medication
- •Self Reported: Uncontrolled cardiovascular, respiratory, neurological, renal, liver, or metabolic health condition
- •Current or recent (regular use within the past six months) use of tobacco, nicotine, nonsteroidal anti-inflammatory products
- •No regular (≥once per week) purposeful heat exposure (e.g., sauna, spa, etc.)
结局指标
主要结局
Plasma neutrophil gelatinase-associated lipocalin (NGAL)
时间窗: Visit 1 (0 months) and Visit 2 (7 months)
Changes in NGAL will be measured in blood samples using enzyme-linked immunosorbent assay.
Urinary neutrophil gelatinase-associated lipocalin (NGAL)
时间窗: Visit 1 (0 months) and Visit 2 (7 months)
Changes in NGAL will be measured in urine samples using radioimmunoassay.
Insulin-like growth factor-binding protein 7 (IGFBP7)*Tissue inhibitor of metalloproteinase-2 (TIMP-2)
时间窗: Visit 1 (0 months) and Visit 2 (7 months)
The product of Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) will be measured in blood samples using enzyme-linked immunosorbent assays.
次要结局
- estimated glomerular filtration rate (eGFR)(Visit 1 (0 months) and Visit 2 (7 months))
研究者
Joseph Watso
Assistant Professor
Florida State University