Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 2
- 主要终点
- Cortical thickness as measured by MRI scans
研究概览
简要总结
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 to 65
- •Previously enrolled in studies of OEF/OIF veterans by the same investigators
- •Free of implanted metal objects or mental shards in eyes
- •Fluent in English and capable of consenting
排除标准
- •Axis I disorders other than Major Depressive Disorder or PTSD
- •Current substance abuse or lifetime substance dependence (other than nicotine)
- •High risk for suicide
- •Claustrophobia
- •Neurological disorders
- •Learning disability or developmental delay
- •Major medical conditions
研究组 & 干预措施
Healthy volunteers
Volunteers with no trauma history
干预措施: MRI (Device)
Healthy volunteers
Volunteers with no trauma history
干预措施: PET (Device)
Healthy volunteers
Volunteers with no trauma history
干预措施: 18F-Florbetapir (Device)
Healthy volunteers
Volunteers with no trauma history
干预措施: Radioligand 18F-AV-1451 (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
干预措施: MRI (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
干预措施: PET (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
干预措施: 18F-Florbetapir (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
干预措施: Radioligand 18F-AV-1451 (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
干预措施: MRI (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
干预措施: PET (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
干预措施: 18F-Florbetapir (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
干预措施: Radioligand 18F-AV-1451 (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
干预措施: MRI (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
干预措施: PET (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
干预措施: 18F-Florbetapir (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
干预措施: Radioligand 18F-AV-1451 (Device)
结局指标
主要结局
Cortical thickness as measured by MRI scans
时间窗: Baseline
Beta amyloid plaques as measured by PET scans
时间窗: Baseline
Tau proteins as measured by PET scans
时间窗: Baseline
次要结局
未报告次要终点