Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural Effusion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Differentiate between malignant and non malignant pleural effusion by pleural markers
研究概览
简要总结
To evaluate the ability of cancer ratio and pleural fluid markers to discriminate between malignant and non malignant effusion
详细描述
Pleural effusion is a common clinical entity affecting approximately 1.5 million patients per year in the United States. {3.1}A large number of diseases may be associated with pleural effusion.
This includes:
- Local conditions affecting the pleura (eg, tuberculous pleurisy, pleural mesothelioma),
- Extrapulmonary diseases with secondary pleural involvement (eg, chronic heart failure, liver cirrhosis).
To date, differentiation between both types of pleural effusion (exudate and transudate) is the most common initial diagnostic approach for patients with pleural effusion.
Exudative effusion is commonly seen in three conditions namely cancer (MPE), tuberculosis (TB) and para pneumonic Although MPE can be diagnosed by simple pleural fluid cytology, this method has significant limitations, including a highly variable sensitivity, ranging from as low as 11.6% to as high as 71%.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients (100 cases) with exudative pleural effusion who will be admitted to Department of Chest diseases and Tuberculosis, Assiut University Hospital
排除标准
- •Age ˂ 18 years
- •Refusal to participate in the study
结局指标
主要结局
Differentiate between malignant and non malignant pleural effusion by pleural markers
时间窗: Baseline
using pleural markers
次要结局
- Time saving(Baseline)