Change of Serum Wnt2 or Wnt4 and the Relationship With Hs-CRP，cTnI and Prognosis in Patients With Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- Serum wnt2 and wnt4 concentration
研究概览
简要总结
This study aims to find the change of serum wnt effectory moleculars and the association with Hs-CRP，cTnI and Prognosis in Patients with Acute Coronary Syndrome.
详细描述
It has been reported that wnt effecory moleculars (wnt2, wnt4, wnt11,wnt10b, DKK1, DKK2) increased in myocardium at acute phase after myocardium infarction in animal experiment. These moleculars can be detected in serum or plasma from human subjects. However, there is few relevant studies about wnt2 and wnt4 concentration in patients with acute coronary syndrome. This study valuates the serum wnt2 and wnt4 concentration in patients with acute coronary syndrome. It will possibly enable to find the relationship between serum wnt2 or wnt4 concentration and Hs-CRP, cTnI and prognosis in patients with Acute Coronary Syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •.diagnosed as acute coronary syndrome, including STEMI and NST-ACS.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked
排除标准
- •• complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent refusal to sign the informed consent
结局指标
主要结局
Serum wnt2 and wnt4 concentration
时间窗: 12 months
Serum wnt2 and wnt4 concentration in ng/ml
次要结局
- Relationship between wnt2 or wnt4 and high sensitive C reaction protein (hs-CRP) concentration(12 months)
- Relationship between wnt2 or wnt4 and Troponin-I (Tn-I) concentration(12 months)
- MACEs during 12-month follow-up(12 months)