Effect of Prednisolone Treatment on Uterine Natural Killer Cells and Endometrial Angiogenesis in Recurrent Miscarriage Around the Time of Embryo Implantation
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- the number of uNK cells
研究概览
简要总结
This study aims to investigate the role of uNK cells and the association with prednisolone.
详细描述
Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations.
The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with a history of 3 or more consecutive miscarriages
- •Women younger than 40 years old
排除标准
- •Allergy to prednisolone
- •Women who have any uterine anomaly
- •Antiphospholipid syndrome
- •Hydrosalpinx
- •Thrombophilia
- •Abnormal thyroid function tests
- •women with diabetes,
研究组 & 干预措施
prednisolone
prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH plus 7. Women will be then given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.
干预措施: Prednisolone (Drug)
结局指标
主要结局
the number of uNK cells
时间窗: at the 1 day of endometrial biopsy
to investigate the association between uNK cells and prednisolone
次要结局
未报告次要终点
研究者
Chung Pui Wah Jacqueline
Associate Professor
Chinese University of Hong Kong