Screening of Specific Genes for Pigmented Villous Nodular Synovitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group
研究概览
简要总结
This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.
详细描述
This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of pigmented villonodular synovitis.
- •Clinical diagnosis of giant cell tumor of tendon sheath
排除标准
- •No surgical treatment.
- •There were no pathological specimens during the operation.
- •The age of the patient is less than 18 years old or more than 60 years old.
- •The operation record shows nodular type.
结局指标
主要结局
Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group
Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group
Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group
Difference of scale score between immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group
Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group
Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group
时间窗: One week after surgery
Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group
次要结局
- Correlation between basic demographic characteristics and scale scores(One week after surgery)