Assessing the impact of high-intensity interval training on the pathophysiology causing obstructive sleep apnoea

Monash University0 个研究点目标入组 24 人开始时间: 2022年6月21日最近更新: 2024年6月18日

适应症

试验速览

暂无简介。

•Moderate/severe OSA (10 =>AHI <= 50 events/hr)
•-Overweight (25 >= BMI <= 35 kg/m2)
•-Engaged in less than or equal to 5 sessions of high intensity training within in the past 6 months
•-Physical activity levels have remained below the following in the past three months
•-<150 minutes of moderate-intensity activity or walking in a typical week; and
•-<75 minutes of vigorous-intensity activity in a typical week
•-At stable medication doses (for greater than 3 months)
•-Diagnosed with OSA and not currently using OSA treatment or are willing to abstain from using OSA treatment for the duration of the study.
•-Epworth Sleepiness Scale (ESS) greater than 16 at screening
•-Not actively trying to lose weight

•-Known or suspected significant cardiovascular, pulmonary, or metabolic disease
•-Uncontrolled hypertension (>159/99 mm Hg)
•-Patients with safety concerns (drowsy driving within the past 2 years)
•-Receiving medication that could affect ventilation (i.e., morphine derivatives, benzodiazepines, theophylline) or muscle control.
•-Previous surgical treatment for OSA and/or obesity
•-Women who are pregnant or currently trying to become pregnant
•-Inability to exercise due to orthopaedic or musculoskeletal problems
•-Score below 2 on the STOP Bang Questionnaire
•-Allergy to any of the local anaesthetics used to insert the genioglossus intramuscular electrodes (e.g. Lidocaine, Lidocaine–Prilocaine). The local anaesthetic is used to reduce the the potential pain or discomfort caused by the insertion of the intramuscular electrodes during the polysomnography which is part of the assessment of study outcomes.

发起方