A comparative study of two different doses of nebulized dexmedetomidine for attenuation of hemodynamic responses to laryngoscopy and intubation.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of nebulized dexmedetomidine [1 mcg / kg] on
研究概览
简要总结
To compare the effect of two different doses of nebulized dexmedetomidine in attenuating the hemodynamic and stress responses to laryngoscopy and intubation in patients undergoing elective surgical procedures under general anaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18-60 years of either sex ASA physical status I/II.
排除标准
- •ASA Grade 3 and 4 Unwillingness to be a part of the trial or patient refusal Allergy to the study drugs Uncontrolled comorbidities [Diabetes mellitus, Hypertension, obese, neurovascular surgeries] and systemic illnesses involving cardiovascular, nervous or respiratory system, any renal or liver disease Hemodynamically unstable patient Pregnancy Anticipated difficult airway / more than 1 attempt / more than 15 seconds for intubation.
结局指标
主要结局
To evaluate the efficacy of nebulized dexmedetomidine [1 mcg / kg] on
时间窗: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at | baseline than after 5 min and 10 min after inhaling nebulization and at | immediately post induction, and subsequently at 1 min interval for 1st 10 | minutes following laryngoscopy and intubation.
hemodynamic responses and on stress response to laryngoscopy and
时间窗: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at | baseline than after 5 min and 10 min after inhaling nebulization and at | immediately post induction, and subsequently at 1 min interval for 1st 10 | minutes following laryngoscopy and intubation.
intubation.
时间窗: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at | baseline than after 5 min and 10 min after inhaling nebulization and at | immediately post induction, and subsequently at 1 min interval for 1st 10 | minutes following laryngoscopy and intubation.
To evaluate the efficacy of nebulized dexmedetomidine [2 mcg / kg] on
时间窗: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at | baseline than after 5 min and 10 min after inhaling nebulization and at | immediately post induction, and subsequently at 1 min interval for 1st 10 | minutes following laryngoscopy and intubation.
hemodynamic and on stress response to laryngoscopy and intubation.
时间窗: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at | baseline than after 5 min and 10 min after inhaling nebulization and at | immediately post induction, and subsequently at 1 min interval for 1st 10 | minutes following laryngoscopy and intubation.
次要结局
- To compare the effect of nebulized dexmedetomidine [1 mcg / kg vs 2(mcg / kg] on hemodynamics and myocardial oxygen demand.)
研究者
Dr Anurag Singh
Department of Anaesthesia , Shri Ram Murti Smarak Institute of Medical Sciences (SRMS IMS)