Flexible Control of Gait in Parkinson Disease: Effect of Task Instruction on the Exploitation of Redundancy in Speed Control.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Stride cadence
研究概览
简要总结
Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients and volunteers able to walk for 20mins and without other neurological disorders.
排除标准
- •Patients or volunteers unable to walk for 20mins and with other neurological disorders.
结局指标
主要结局
Stride cadence
时间窗: Measured during the entire experiment (an average of 4.5 years)
Time between two consecutive heel strikes. Units are seconds.
Stride amplitude
时间窗: Measured during the entire experiment (an average of 4.5 years)
Distance between two consecutive heel strikes. Units are meters.
次要结局
未报告次要终点
