VITACOV: Vitamin D-related Polymorphisms and Vitamin D Levels as Risk Biomarkers of COVID-19 Infection Severity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 517
- 试验地点
- 3
- 主要终点
- Differences in vitamin D blood levels between COVID-19 patients with different degrees of disease severity.
研究概览
简要总结
Vitamin D deficiency has been linked to hypertension, autoimmune, infectious and cardiovascular diseases which are risk factors for COVID-19. Moreover, COVID-19 patients have a very high prevalence of hypovitaminosis D (Turin data). Taken together, we aim to investigate whether genetic variants in vitamin D-related genes contribute to a poor COVID-19 outcome, particularly in hypertension and CV patients, proposing thus a personalized therapeutics based on vitamin D supplementation in order to reduce the severity and deaths.
详细描述
Collected data from Turin University indicate that hospitalized patients have a very high prevalence of hypovitaminosis D. Reports from China and Italy show that hypertension presents an increased risk of COVID-19-related death. Otherwise, observational studies suggest that 25(OH)D induces protection against respiratory pathogens while large-scale studies indicate that serum 25(OH)D-level is inversely correlated to hypertension prevalence. Recent published data (2020) shows that 66% of Portuguese adults present Vitamin D deficiency. HeartGenetics' genetic database with more than 8.500 Portuguese genotypes shows that the prevalence of vitamin D polymorphisms in this population is 4-fold higher than the EU average, increasing the risk of hypovitaminosis D.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults of 18 years and above.
- •COVID-19 patients admitted with mild to severe disease (admission to isolation room) or critical patients (admission to ICU).
- •Available to comply with study protocol and sign informed consent.
排除标准
- •Patients diagnosed with COVID-19 not admitted to hospital.
- •Patients unable to provide informed consent.
结局指标
主要结局
Differences in vitamin D blood levels between COVID-19 patients with different degrees of disease severity.
时间窗: Blood samples of COVID-19 patients will be collected at baseline (after subject enrollment; single point collection).
Differences in genetic variants in vitamin D-related genes between COVID-19 patients with different degrees of disease severity.
时间窗: Blood samples of COVID-19 patients will be collected at baseline (after subject enrollment; single point collection).
次要结局
- Differences in vitamin D blood levels between COVID-19 patients in relation to duration of mechanical ventilation.(Through study completion, an average of 3 months.)
- Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to length of stay in hospitals.(Through study completion, an average of 1 year.)
- Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to duration of mechanical ventilation.(Through study completion, an average of 3 months.)
- Differences in vitamin D blood levels between COVID-19 patients in relation to mortality.(Through study completion, an average of 3 months.)
- Differences in vitamin D blood levels between COVID-19 patients in relation to length of stay in hospitals.(Through study completion, an average of 3 months.)
- Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to mortality.(Through study completion, an average of 3 months.)
研究者
Fausto J. Pinto
Professor
University of Lisbon