NCT01273831已完成2 期
Study of Effects of Cisatracurium and Atracurium on Intraocular Pressure
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- intraocular pressure
研究概览
简要总结
The purpose of this study is to determine which drug makes lower intraocular pressure
详细描述
Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.
排除标准
- •difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%
研究组 & 干预措施
atracurium
Other
Patients who underwent general anesthesia received atracurium
干预措施: atracurium (Drug)
cisatracurium
Other
Patients who underwent general anesthesia received cisatracurium
干预措施: cisatracurium (Drug)
结局指标
主要结局
intraocular pressure
时间窗: at 2 minutes after intubation
determining intraocular pressure in atracurium and cisatracurium groups
次要结局
- systolic blood pressure(at 2 minutes after intubation)
研究者
研究点 (1)
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