Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Sensitivity of anti-carbamylated protein antibodies for the diagnosis of psoriatic arthritis in the psoriatic population
研究概览
简要总结
Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic arthritis. The investigators hypothesized that detection of anti-CarP antibodies in serum may be useful for diagnosis of psoriatic arthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •"Controls" : Patients with a psoriasis confirmed by a dermatologist and with absence of psoriatic arthritis confirmed by a rheumatologist.
- •"Cases" : Patients with psoriatic arthritis fulfilling the classification criteria for psoriatic arthritis (CASPAR), with a diagnosis confirmed by a rheumatologist and associated with personal or familial psoriasis.
排除标准
- •"Controls": Presence of any chronic rheumatic inflammatory disease such as psoriatic arthritis.
研究组 & 干预措施
Controls
Patients with psoriasis and without psoriatic arthritis.
干预措施: Serum anti-CarP antibodies detection (Diagnostic Test)
Cases
Patients with psoriatic arthritis and with personal or familial psoriasis.
干预措施: Serum anti-CarP antibodies detection (Diagnostic Test)
结局指标
主要结局
Sensitivity of anti-carbamylated protein antibodies for the diagnosis of psoriatic arthritis in the psoriatic population
时间窗: Anti-CarP antibodies will be assessed in the sera collected at the recruitment visit
次要结局
未报告次要终点