The Impact of Mediterranean Diet on Patients With Hashimoto Thyroiditis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes in the serum level of free T3
研究概览
简要总结
Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and is one of the most common causes of hypothyroidism. Eating habits may affect the risk of several inflammatory and immune diseases, such as HT. The current knowledge of the diet in HT is insufficient. The Mediterranean diet (MD) is an anti-inflammatory diet characterized by frequent consumption of olive oil, unrefined cereals, fresh or dried fruit and vegetables, moderate amounts of fish, dairy, and meat, and many condiments and spices. It is rich in nutrients and bioactives, which have the potential to offer anti-inflammatory aspects.
详细描述
The investigators aimed to assess the impact of the Mediterranean diet on patients with Hashimoto thyroiditis using the following outcomes:
Primary outcomes: Anti-TPO antibodies, Anti-Thyroglobulin antibodies, TSH, T3, T4 Secondary outcomes: BMI, Lipid profile, Symptoms of hypothyroidism
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with symptoms of hypothyroidism (hypothyroid/euthyroid)
- •Positive anti-thyroid antibodies (anti-TPO/anti-TG).
排除标准
- •Pregnant or lactating females
- •Age below 20 years and above 50 years
- •presence of any other medical disorder
结局指标
主要结局
Changes in the serum level of free T3
时间窗: after 3 months of dietary modification
pg/ml
Changes in the serum level of free T4
时间窗: after 3 months of dietary modification
ng/dl
Changes in the serum level of anti-TPO and Anti-TG antibodies
时间窗: after 3 months of dietary modification
IU/ml
Changes in the serum level of TSH
时间窗: after 3 months of dietary modification
uIU/ml
次要结局
- changes in serum level of total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein(after 3 months of intervention)
- Symptoms of hypothyroidism(after 3 months of intervention)
- changes in BMI(after 3 months of intervention)
研究者
Sherihan AboElyazed Mohamed Khalil
Lecturer of Endocrinology and Internal Medicine Faculty of Medicine, Ain Shams University Cairo, Egypt
Ain Shams University