Prefrontal Neuroplasticity and Coping Strategies in Healthy Population: a Randomized Sham Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- iTBS induced prefrontal cortex activity and connectivity
研究概览
简要总结
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-60 years old;
排除标准
- •a family history of psychiatric disorders;
- •history of or currently diagnosed neuropsychiatric conditions;
- •history of or active systemic illnesses such as cancer, epilepsy, diabetes, hypertension, or other medical conditions;
- •contraindications to transcranial magnetic stimulation (TMS);
- •any prior exposure to brain stimulation procedures.
研究组 & 干预措施
Real Stimulation
Participants in this arm will receive a real session of iTBS over the left dorsolateral prefrontal cortex
干预措施: Transcranial Magnetic Stimulation (Device)
Sham Stimulation
Participants in this arm will receive a sham session of iTBS over the left dorsolateral prefrontal cortex
干预措施: Transcranial Magnetic Stimulation (Device)
结局指标
主要结局
iTBS induced prefrontal cortex activity and connectivity
时间窗: 3 minutes before, during, and after the stimulation
iTBS induced prefrontal cortex activity and connectivity
时间窗: 3 mins before, during, and after the stimulation
次要结局
- perceived stress scale(the same day before conducting the experiment)
- coping inventory for stressful situations(the same day before conducting the experiment)
研究者
Dr Georg Kranz
Associated Professor
The Hong Kong Polytechnic University