The Relationship Between Bone Mineral Density, Disease Duration, and Activity in Patients With Ankylosing Spondylitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Bath ankylosing spondylitis disease index (BASDAI)
研究概览
简要总结
Our clinical study aimed to evaluate the prevalence of osteoporosis (OP) in patients with ankylosing spondylitis (AS) and to investigate the relationship between clinical, disease activity, physical function and disease duration, and bone mineral density (BMD).
详细描述
In this cross-sectional study, patients who were admitted to the rheumatology clinic between 18 and 65 years of age and diagnosed as AS according to the modified New York diagnostic criteria were included
Patients group was divided two part as patients with (group 1)and without (group 2) osteoporosis.
The patient's global rating scale is a self-assessed scale of the patient with a grade of 10 (1: very bad, 5: moderate, 10: very good). To assess the disease activity, Bath ankylosing spondylitis disease index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI) were evaluated. BASDAI is a self-assessment scale used to determine disease activity in patients with AS.
Schober measurement was used to evaluate lumbar mobility of the patients. Chest expansions were measured in all patients.
Body mass index (BMI) was calculated as kg/height m2. Erythrocyte sedimentation rate (ESH mm / h), C-reactive protein (CRP mg / l) levels were measured in all patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed as AS according to the modified New York diagnostic criteria were included
排除标准
- •Patients previously diagnosed with OP,
- •Patients previously treated with OP,
- •Patients with bone fractures previously associated with OP,
- •Those using drugs that affect bone metabolism, metabolic bone diseases (Paget's -disease, osteomalacia, hyperparathyroidism),
- •Diabetes mellitus,
- •Hypothyroidism, hyperthyroidism,
- •Patients with kidney, liver and intestinal diseases,
- •Those using corticosteroids
结局指标
主要结局
Bath ankylosing spondylitis disease index (BASDAI)
时间窗: up to 6 month
BASDAI, is a widely used patient-reported outcome to measure disease activity in AS. It comprises only six questions (Box 5.1). The answers to these questions are scored on a 0-10 NRS, which are anchored by 0 ("none") to 10 ("very severe"). The BASDAI sum score is calculated by the sum of questions 1-4 plus mean of questions 5 and 6, the total then divided by 5. The sum score ranges from 0 to 10, higher values indicate more active disease.
Bath ankylosing spondylitis functional index (BASFI)
时间窗: up to 6 month
Bath Ankylosing Spondylitis Functional Index (BASFI): this is the most frequently used tool to asses function in AS. It contains 10 questions on activities of daily living, which are scored with a rating scale from 0 (no functional impairments) to 10 (maximal impairment). The sum score ranges from 0 to 10, with higher values indicating worse functioning.
次要结局
未报告次要终点
研究者
Yaşar Keskin
Department of Physical Medicine and Rehabilitation, Principal Investigator, Medical Doctor
Bezmialem Vakif University