Cough Determinants in Mechanically Ventilated Patients: a Physiological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 4
- 主要终点
- Interest of systematically cough evaluation before extubation
研究概览
简要总结
In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough. In order to determine some determinants of cough, the investigators propose to evaluate systematically different physiological parameters before and after extubation.
详细描述
In order to evaluate, and identify the cough determinants, the investigators propose a physiological evaluation for each patients who were intubated and mechanically ventilated during at least 72 hours. Indeed inefficacy of cough after extubation is one of the main reason of extubation failure. However there is no any mean to evaluate it simply now.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients mechanically ventilated since 72h
- •Age > 18 years
- •Hospitalized in Intensive care Unit
- •In weaning phase - with the classically criteria to be extubated
- •Patients who passed the weaning test (T tube test or other)
排除标准
- •Hemodynamic instability
- •Absence of consent
- •No cooperation of the patient
- •Hemodynamic instability
- •pH < 7,30
- •Severe hypoxemia
研究组 & 干预措施
Cough Determinants
干预措施: Functional respiratory evaluation (Other)
结局指标
主要结局
Interest of systematically cough evaluation before extubation
时间窗: 2 days after extubation
All the patients enrolled have a physiological evaluation before and after extubation. After extubation the evaluation will be done respectively at D0, D1, D3 and D5. The first endpoint is the success of extubation which is evaluated à D2.
次要结局
- Correlation between success of extubation and respiratory parameters(2 days after extubation)