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临床试验/NCT05579795
NCT05579795尚未招募不适用

Tethered Cord Syndrome: Surgical Management and Outcome

Assiut University0 个研究点目标入组 35 人开始时间: 2022年11月2日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
35
主要终点
Motor power

研究概览

简要总结

The aim of this study is to assess surgical management and outcome of Tethered cord syndrome

详细描述

Tethered cord syndrome (TCS) is a developmental abnormality of the neuroaxis which is usually diagnosed in childhood. The actual tethering has been attributed to a variety of pathologic entities, including a thickened tight filum terminale , intradural lipomas with or without a connecting extradural component, intradural fibrous adhesions, diastematomyelia, and adherence of the neural placode following previous closure of a myelomeningocele. However, sufficient differences in the mode of onset, clinical manifestations, and outcome exist between pediatric and adolescent patients with tethered cord to warrant a more detailed analysis of the adult syndrome. The most problematic technical consideration in surgery for the release of the tethered cord is how to preserve functioning neural elements and rebuild the dural sac to avoid CSF leak. The purpose of this study is to review causes of Tethered cord, clinical presentation, diagnostic tools, treatment options and outcome in school-aged children, adolescents, and young adults with Tethered cord.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
1 Year 至 16 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Patients with Tethered cord syndrome presenting at our institute
  • Patients with spinal dysraphism
  • Lipomyelomeningocele with Tethered cord
  • patients presented with neurological deficit after lipomyelomeningocele repair due to Tethered cord
  • patients presented with neurological deficit after myelomeningocele repair due to Tethered cord
  • Diastematomyelia with Tethered cord - Tethered cord due to filum terminale.
  • Tethered cord due to fibrous adhesions

排除标准

  • Asymptomatic Patients with Tethered cord discovered accidentally

结局指标

主要结局

Motor power

时间窗: Two years

Outcome of Detethering of the Tethered spinal cord according to Motor power of the lower limbs 5 grades 0: No visible muscle contraction 1. Visible muscle contraction with no or trace movement 2. Limb movement, but not against gravity 3. Movement against gravity but not resistance 4. Movement against at least some resistance supplied by the examiner 5. Full strength

Sensations

时间窗: Two years

Outcome of Detethering of the Tethered spinal cord according to the sensations of lower limbs , is there decreased sensations of lower limbs and if improved or not

Sphincter's function

时间窗: Two years

Outcome of Detethering of the Tethered spinal cord according to is there urinary incontinence or stool incontinence and if improved or not

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Amr Gamal Hussein Mohamed

Principal Investigator

Assiut University

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