Tethered Cord Syndrome: Surgical Management and Outcome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 35
- 主要终点
- Motor power
研究概览
简要总结
The aim of this study is to assess surgical management and outcome of Tethered cord syndrome
详细描述
Tethered cord syndrome (TCS) is a developmental abnormality of the neuroaxis which is usually diagnosed in childhood. The actual tethering has been attributed to a variety of pathologic entities, including a thickened tight filum terminale , intradural lipomas with or without a connecting extradural component, intradural fibrous adhesions, diastematomyelia, and adherence of the neural placode following previous closure of a myelomeningocele. However, sufficient differences in the mode of onset, clinical manifestations, and outcome exist between pediatric and adolescent patients with tethered cord to warrant a more detailed analysis of the adult syndrome. The most problematic technical consideration in surgery for the release of the tethered cord is how to preserve functioning neural elements and rebuild the dural sac to avoid CSF leak. The purpose of this study is to review causes of Tethered cord, clinical presentation, diagnostic tools, treatment options and outcome in school-aged children, adolescents, and young adults with Tethered cord.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 16 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with Tethered cord syndrome presenting at our institute
- •Patients with spinal dysraphism
- •Lipomyelomeningocele with Tethered cord
- •patients presented with neurological deficit after lipomyelomeningocele repair due to Tethered cord
- •patients presented with neurological deficit after myelomeningocele repair due to Tethered cord
- •Diastematomyelia with Tethered cord - Tethered cord due to filum terminale.
- •Tethered cord due to fibrous adhesions
排除标准
- •Asymptomatic Patients with Tethered cord discovered accidentally
结局指标
主要结局
Motor power
时间窗: Two years
Outcome of Detethering of the Tethered spinal cord according to Motor power of the lower limbs 5 grades 0: No visible muscle contraction 1. Visible muscle contraction with no or trace movement 2. Limb movement, but not against gravity 3. Movement against gravity but not resistance 4. Movement against at least some resistance supplied by the examiner 5. Full strength
Sensations
时间窗: Two years
Outcome of Detethering of the Tethered spinal cord according to the sensations of lower limbs , is there decreased sensations of lower limbs and if improved or not
Sphincter's function
时间窗: Two years
Outcome of Detethering of the Tethered spinal cord according to is there urinary incontinence or stool incontinence and if improved or not
次要结局
未报告次要终点
研究者
Amr Gamal Hussein Mohamed
Principal Investigator
Assiut University
