Integrated exposure-based therapy for co-occurring post-traumatic stress disorder and alcohol dependence: effects of the FAAH inhibitor PF-04457845 on extinction. A randomized controlled trial.

Stockholm Centre for Dependency Disorders (Sweden)0 个研究点目标入组 120 人开始时间: 2014年8月13日最近更新: 2018年11月19日

适应症

试验速览

暂无简介。

•2. Age >18 years
•3. Diagnosed with current PTSD and current alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV), as determined by The Structured Clinical Interview for DSM IV Disorders (35) and clinical examination by a psychiatrist.

•1. Current DSM-IV substance dependence other than nicotine, as determined by the SCID and clinical examination by a psychiatrist and negative urine screen for illicit drugs.
•2. Current DSM-IV psychotic, as determined by the SCID, and clinical examination by a psychiatrist.
•3. Clinically significant suicidal or homicidal ideation on clinical assessment with the relevant section of The Mini International Neuropsychiatric Interview (MINI; (36)) and clinical examination by a psychiatrist.
•4. Any current medication or medical condition that in the judgment of the investigator could interfere with treatment.
•5. Pregnancy or nursing. To be eligible, women of childbearing potential must have a negative serum or urine pregnancy test prior to the start of study drug, and agree to using a method of contraception that is adequate in the judgment of the investigator for the duration of the study.
•6. Insufficient memory of the trauma (for prolonged exposure to be effective).
•7. Dissociative disorder which is more severe or affects the subject more than her PTSD.

发起方

Stockholm Centre for Dependency Disorders (Sweden)