Handgrip Training and Brain Blood Flow Regulation

The incidence of cerebrovascular diseases is expected to increase. Early life sets the stage for vascular health outcomes later in life. Regular exercise is recommended for improving cerebrovascular health outcomes, but a lack of time or inadequate facilities are common exercise barriers. Not getting enough exercise is associated with worse cardiovascular and cerebrovascular health outcomes. There is a critical need for time-efficient strategies that require minimal equipment for improving cardiovascular and cerebrovascular health. Isometric handgrip (IHG) training is an effective strategy for improving cardiovascular health. Despite IHG's usefulness for improving vascular health through blood pressure reductions and improvements in endothelial function, almost nothing is known about IHG training and cerebrovascular function. Therefore, this project aims to test the hypothesis that 8 weeks of IHG training will improve cerebrovascular blood flow regulation and total cerebrovascular blood flow among adult humans who are not meeting the physical activity recommendations. We will measure middle cerebral artery blood velocity (MCAv) via transcranial Doppler ultrasound and assess MCAv dynamic autoregulation and MCAv reactivity to high and low carbon dioxide. We will also measure total cerebral blood flow, central artery stiffness, and MCAv pulsatility index. Understanding the effect of IHG on cerebrovascular health could inform exercise recommendations.