Thermal Quantitative Sensory Testing as a Method to Semi-quantitatively Assess the Neurosensory Effects of 3 Local Anesthetic Solutions in an Interscalene Block
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Presence of sensory block
研究概览
简要总结
Thermal quantitative sensory testing (QST) is a method to evaluate peripheral nerve blocks in a quantitative way. It assesses the neurosensory effects of local anesthetics, like nerve block intensity, duration, recovery, neurotoxicity, the effect of spread of local anesthetic solutions and the effect and the eventual neurotoxicity of adjuvants. We aimed at investigating, in a quantitative way, the block characteristics of 3 different commonly used local anesthetics on peripheral nerves through the application of thermal QST by measuring changes in sensory detection thresholds. Furthermore, we wanted to evaluate if QST could be of value for measuring gradual changes in block characteristics on the adjacent nerves at distance of the injection site in an US-ISB.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients scheduled for diagnostic and therapeutic shoulder arthroscopy, with or without decompression technique were eligible
排除标准
- •contraindications for ISB
- •diabetes mellitus
- •peripheral neuropathy
- •patients receiving chronic analgesic therapy
- •contraindications for NSAID
- •patients with an initial QST with abnormal values
研究组 & 干预措施
Levobupivacaine 0,5%
Levobupivacaine 0,5% 15 ml once
干预措施: Interscalene block (Procedure)
Levobupivacaine 0,5% with epinephrine
Levobupivacaine 0,5% with 1/200000 epinephrine 15 ml once
干预措施: Interscalene block (Procedure)
Ropivacaine 0,75%
Ropivacaine 0,75% 15 ml once
干预措施: Interscalene block (Procedure)
结局指标
主要结局
Presence of sensory block
时间窗: 24 hours after intervention
次要结局
- Block duration(24 hours after intervention)
- Degree of sensory stimulus detection threshold variation from baseline values(24 hours after intervention)
- Presence of motor block(24 hours after intervention)
- Use of rescue medication(24 hours after intervention)
研究者
Ethisch Comité UZ Antwerpen
Thermal Quantitative Sensory Testing as a method to semi-quantitatively assess the neurosensory effects of 3 local anesthetic solutions in an interscalene block
University Hospital, Antwerp