A Randomised Control Trial to Assess the Efficacy of Short-term, Home-based High- Intensity Interval Training (HIT) for Improving Indices of Cardiorespiratory Fitness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Change in VO2 Max (L/min) assessed by Cardio-pulmonary exercise test (CPET)
研究概览
简要总结
This study will aim to evaluate the efficacy of a short-term, home-based, high-intensity interval (HIT) programme in improving cardiovascular fitness in healthy volunteers aged 55 and above, with an age-comparison to younger individuals taking part in the same training regime.
It will also explore the efficacy of time-matched 'static' interventions for improving cardiovascular parameters in middle-aged females and older adults.
详细描述
Patients with lower peak oxygen uptake have higher mortality and morbidity when undergoing major surgery. Aerobic fitness is a potentially modifiable risk factor for postoperative complications.
Traditional pre-operative exercise interventions to improve fitness involve high time and supervision-demands, often resulting in poor compliance. High-intensity interval training (HIT) is a time-efficient, feasible method to improve pre-operative fitness, however current studies only involve exercise in the laboratory setting.
Study Design Thirty-six healthy volunteers aged 55y and over will be randomly allocated to one of three groups: 1) Laboratory-HIT; 2) Home-HIT; 3) No intervention. All HIT sessions will involve a brief warm-up, followed by five 1-minute bouts of high-intensity (body-weight based) exercise, interspersed with 90-seconds recovery, concluding with a brief cool-down. The primary endpoint of the study is change in VO2 peak with secondary endpoints of changes in: anaerobic threshold, insulin sensitivity and muscle mass.
Subjects will be expected to perform up to a maximum of 16 HIT sessions (maximum 5 sessions per week) within a period of 31 days. Aerobic fitness will be assessed prior to and following the exercise, as will body composition, muscle structure, physical function and insulin sensitivity.
For the age comparison, 24 young individuals will be recruited to either a control or home-HIT arm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 55 years Able to give informed consent
排除标准
- •Current participation in a formal exercise regime
- •A BMI < 18 or > 35 kg·m2
- •Active cardiovascular disease:
- •Uncontrolled hypertension (BP > 160/100)
- •Heart failure (class III/IV)
- •Significant arrhythmia
- •Right to left cardiac shunt
- •Recent cardiac event
- •Taking beta-adrenergic blocking agents
- •Cerebrovascular disease:
- •Previous stroke
- •Aneurysm (large vessel or intracranial)
- •Respiratory disease including:
- •Pulmonary hypertension
- •Significant COPD
- •Uncontrolled asthma
- •Malignancy
- •Metabolic disease e.g. diabetic patients
- •Clotting dysfunction
- •Significant Musculoskeletal or neurological disorders
- •Family history of early (<55y) death from cardiovascular disease
研究组 & 干预措施
Laboratory HIT
Supervised (Laboratory HIT) exercise in the lab up to 4 times per week for 4 weeks
干预措施: High-intensity interval training (Other)
Home HIT
Unsupervised (Home HIT) exercise at home up to 4 times per week for 4 weeks
干预措施: High-intensity interval training (Other)
Control Group
No intervention
结局指标
主要结局
Change in VO2 Max (L/min) assessed by Cardio-pulmonary exercise test (CPET)
时间窗: 31 days
To determine the efficacy of bodyweight HIT for improving aerobic fitness
次要结局
- Change in Anaerobic Threshold (L/min) using CPET(31 days)
- Change in resting glucose and insulin sensitivity (mmol/L)(31 days)
- Change in muscle architecture as assessed by ultrasound(31 days)
- Change in body composition (fat, muscle, bone (g)) as assessed by Dual-energy Xray Absorptiometry (DEXA)(31 days)
- Feasibility of home HIT assessed using a preset feasibility questionnaire(31 days)
研究者
Bethan Phillips
Assistant Professor
University of Nottingham