Influence of Probiotic and Symbiotic in Body Weight, Blood Sugar and Lipemia of Obese Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Evaluate the effect of probiotic and symbiotic on weight loss of women obese
研究概览
简要总结
The purpose of this study is to evaluate whether gut microbiota modulation by probiotic and symbiotic contribute with weight loss and improvement of metabolic parameters in women with obesity.
详细描述
We will evaluate the effects of probiotic and symbiotic on weigh loss, blood glucose, lipid profile, metabolomic profile, and gut microbiota composition variables in women with obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Obese (BMI between 30 and 39,9 Kg/m²).
排除标准
- •Pregnancy or nursing;
- •Drinkers;
- •Use of drug or phytotherapic;
- •Diagnosis of any cronic disease;
- •Daily consumption of yogurt.
研究组 & 干预措施
Symbiotic
Hypocaloric diet associated with capsule containing 1billion UFC Bifidobacterium lactis and sache with 5 g of fructooligosaccharide
干预措施: Symbiotic (Dietary Supplement)
Placebo
Hypocaloric diet associated with capsule containing 50g of gelatin and sache with 5 g of maltodextrin
干预措施: Placebo (Dietary Supplement)
Probiotic
Hypocaloric diet associated with capsule containing 1billion UFC Bifidobacterium lactis and sache with 5 g of maltodextrin
干预措施: Probiotic (Dietary Supplement)
结局指标
主要结局
Evaluate the effect of probiotic and symbiotic on weight loss of women obese
时间窗: Baseline and 60 days and 15 days after the end of the intervention
Determine and evaluate change in body weight and body mass index after intervention.
次要结局
- Effect of probiotic and symbiotic on blood glucose(Baseline, 60 days and 15 days after the end of the intervention)
- Effect of probiotic and symbiotic on insulin resistance(Baseline and 60 days)
- Effect of probiotic and symbiotic on metabolomic profile(Baseline and 60 days)
- Effect of probiotic and symbiotic on lipid profile(Baseline and 60 days)
- Effect probiotic and symbiotic on blood pressure(Baseline,60 days and 15 days after intervention conclusion)
- Effect of probiotic and symbiotic on gut microbiota composition(Baseline, 60 days and 15 days after intervention conclusion)
- Effect of probiotic and symbiotic on stool consitency by Bristol scale(Baseline,60 days and 15 days after intervention conclusion)
- Effect of probiotic and symbiotic on gastrointestinal symptons(Baseline,60 days and 15 days after intervention conclusion)
研究者
Louise Crovesy de Oliveira
Principal investigator
Universidade Federal do Rio de Janeiro