Study of the effect of vitamine D3 on incidence of exacerbations and infections of ‘chronic obstructive pulmonary disease’ patients (COPD) with serum levels of vitamine D less than 75 nmol/L.

Iran University of Medical Sciences0 个研究点目标入组 66 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•Inclusion criterial: All COPD patients including those with emphysema and chronic bronchitis with serum vitamin D-25 level less than 75 nmol/L.
•Exclusion criterial: 1. patients younger than 40 yrs; 2. patients with FEV1/FVC < 70%; 3. patients that after inhalation of 400 microgra salbutamol have FEV1/FVC > 70%; 4. patients with history of consumtion of less than 15 pack year cigarettes; 5. patient with asthma or history of asthma; 6. patients with serum level of vitamine D > 75 mnol/L; 7. patients with diabetes, renal failure, history of MI, bronchiectasia, sarcoidosis, hypoparathyroidism, nephrolithiasis, active TB, liver failure, malignancy with remission less than 3 years age; 8. patients under treatment with carbamazepine, cardiac glycosides, phenobarbital, phenytoin, perimidon; 9. patients with serum calcium level above 2.65 mmol/L or serum creatinine level above 125 micromol/L; 10. patients unable to cooperate with spirometery; 11. patient who need to receive more than 12 hrs per day oxygen.

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