The Study of Gut Microbiota in Hypertensive Patients
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- The difference of gut microbiota composition between the two groups
研究概览
简要总结
Recent animal and human studies have found the relationship between the composition of the gut microbiota and hypertension, but some studies did not have a detailed evaluation of the diet content, which could be an important effect on gut microbiota. Moreover, most of these studies were finished in Western countries, in which the dietary patterns were significantly different from those in Chinese regions. This study intends to establish Taiwanese local data to explore the differences in the composition of gut microbiota among hypertensive patients and normotensive subjects.
详细描述
The investigators plan to enroll total 70 hypertensive and normotensive cases from the elderly health examination in Cathay General Hospital, who are aged from 65 to 80 years. Body mass index and blood samples for biochemical analysis such as blood sugar and cholesterol levels are taken, and fecal samples are collected for analysis of gut microbiota, which is characterized by 16S ribosomal RNA gene sequencing. Besides, the diet and nutrients intake are recorded and calculated by licensed dietitian. Through the exploration of gut microbiota in hypertensive patients, the results can be the reference for clinical treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 65~80 years old
- •People who join the Elderly Health Examination Program in Cathay General Hospital in 2021
排除标准
- •Antibiotics use within one month
- •Acute gastrointestinal illness within one week, such as vomiting and diarrhea
- •History of gastrointestinal surgery
- •History of inflammatory bowel disease
- •Chronic gastrointestinal disease under medication treatment
- •Cannot finish dietary record
结局指标
主要结局
The difference of gut microbiota composition between the two groups
时间窗: immediately after the enrollment completes
The differential OTUs (operational taxonomic units) between the two groups
次要结局
未报告次要终点