NCT05823454招募中不适用
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness Based on Electroencephalogram and Event-related Potential
Beijing Tiantan Hospital1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2022年9月30日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- EEG Spectral Characteristics
研究概览
简要总结
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 - 65 years old, native Chinese speaker, dextromanuality;
- •Chronic disorder of consciousness;
- •Spinal cord electrical stimulator implantation under general anesthesia;
- •Signed informed consent.
排除标准
- •Continuous sedation was administered within 72 hours prior to the study;
- •Open head injury, parenchymatectomy and other damage of brain structural integrity;
- •The intracranial compliance decreased due to hydrocephalus and swelling;
- •Known hearing impairment;
- •Airway stenosis and various causes of severe ventilation or ventilation dysfunction;
- •Known or suspected cardiac dysfunction;
- •Allergic to intravenous general anesthetics;
- •Associated with other mental or neurological diseases;
- •Other reasons are not suitable to participate in this study.
研究组 & 干预措施
Propofol
Intravenous infusion
干预措施: Different drug dosage (Drug)
Dexmedetomidine
Intravenous infusion
干预措施: Different drug dosage (Drug)
Esketamine
Intravenous infusion
干预措施: Different drug dosage (Drug)
Sevoflurane
Inhalation anesthesia
干预措施: Different drug dosage (Drug)
Remifentanil
Intravenous infusion
干预措施: Different drug dosage (Drug)
结局指标
主要结局
EEG Spectral Characteristics
时间窗: During the trial(up to 3 hours for each subject)
Characteristics of EEG power spectrum(for 1-30 Hz) in patients with chronic consciousness disorder under different doses of drugs
次要结局
- Cortical Connectivity(During the trial(up to 3 hours for each subject))
- Derived quantitative indicators(During the trial(up to 3 hours for each subject))
- Dynamic Patterns of Cortical Connectivity(During the trial(up to 3 hours for each subject))
- Characteristics of sleep(During the trial(up to 24 hours for each subject))
- Rate of patients recovered consciousness after surgery(During the trial(through study completion, 180 days))
研究者
Ruquan Han
Professor
Beijing Tiantan Hospital
研究点 (1)
Loading locations...
相似试验
已完成
4 期
Neuronal Inertia in Propofol AnesthesiaGeneral AnesthesiaPropofol PharmacodynamicsPropofol Target Controlled InfusionLoss of Consciousness and Recovery of ConsciousnessPropofol Plasma ConcentrationNCT01962285Universidad del Desarrollo14
已完成
不适用
Sedation and Neuromediators ConcentrationModerate SedationDeep SedationNCT04695509I.M. Sechenov First Moscow State Medical University24
已完成
不适用
Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.Functional AnesthesiaNCT03140982Universidad del Desarrollo16
Unknown
不适用
Effects of Repeated Intravenous Anesthesia With Propofol on the Postoperative Neurological Function of Patients Undergoing Hysteroscopic SurgeryPNDAnesthesiaNCT05297682The Third Xiangya Hospital of Central South University258
已完成
不适用
To Study the Effect of Sevoflurane and Propofol V Sevoflurane and Dexmedetomidine on Postoperative Cognitive DysfunctionPostoperative Cognitive DysfunctionNCT03145714Rajiv Gandhi Cancer Institute & Research Center, India60