Comparative Analysis of Indocyanine Green Clearance Test, MELD Score, MELD-Na Score, Transient Elastography and Hepatic Venous Pressure Gradient to Evaluate Prognosis of Patients on Liver Transplant Waiting List
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- All cause mortality
研究概览
简要总结
It is a cohort to evaluate the power of different diagnostic tests in predicting the prognosis of patients with severe liver disease.
Patients with decompensated liver cirrhosis on the waiting list for liver transplantation will be evaluated with comparison of different diagnostic tests according to the MELD score (Model for End-Stage Liver Disease), MELD-Na (Model for End-Stage Liver Disease and sodium), indocyanine green clearance test, hepatic venous pressure gradient and transient elastography. All patients will be submitted to all the tests and prospectively followed for 6 months, to establish mortality and complications related to liver disease in order to define the value of each method to predict outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the study includes patients (80 patients)
- •were male and female
- •aged between 18 and 69 years with chronic liver disease
- •with MELD inclusion greater than or equal to 14 to 30
排除标准
- •they have been transplanted
- •have a diagnosis of primary malignant liver (HCC) signed by imaging tests performed
- •MELD scores greater than 30.
结局指标
主要结局
All cause mortality
时间窗: 6 months
Mortality within 6 months after evaluation, classifying as related or non-related to liver disease
次要结局
- Chronic liver failure and portal hypertension complications(6 months)
研究者
Guilherme Rezende
Associate Professor, MD PhD
Universidade Federal do Rio de Janeiro