Comparison of Acute Tart Cherry Supplement Formulation and Dose on Inflammation and Oxidative Capacity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 主要终点
- Change in c-reactive protein
研究概览
简要总结
A comparison of acute tart cherry formations (juice vs. powdered) and doses (single vs. twice daily) on inflammation and oxidative capacity.
详细描述
Participants will be randomly allocated to a group: one tart cherry capsule daily, two tart cherry capsules daily, one 8oz. bottle of tart cherry juice daily, two 8oz. bottles of tart cherry juice taken 8 hours apart, one placebo pill, and one 8oz. bottle of placebo. Participants will arrive to the lab at 8 am after an overnight fast of 10 hours. They will provide a blood sample and then ingest their study treatment. Participants will stay in the lab for a further 2 hours for additional blood draws then return to the lab in 6 hours for another blood draw. At this time if they are in a twice daily group they will receive their second treatment for the day. All participants will come back to the lab 24 hours later where they will give a blood sample and receive their next treatment. If they are in the twice daily group they will be provided with their next dose and given instructions to consume it in 8 hours. Participants will arrive 24 hours later for a final blood draw with no supplementation.
Blood samples will be measured pre-ingestion, 1 hour, 2 hours, 8 hours, 24 hours and 48 hours post-ingestion. Samples will be analyzed for plasma oxygen radical absorbance capacity (ORAC), uric acid (UA), and C-reactive protein (CRP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •free of cardiovascular, metabolic and inflammatory conditions
- •non-smokers
- •no known allergy to cherries or cherry juice
- •not be taking food supplements (turmeric/curcumin, cherry products, greens, etc.).
排除标准
- •quit smoking less than one year ago.
- •currently being treated for arthritis or an inflammatory condition.
- •currently being treated for uncontrolled cardiovascular disease, high blood pressure, diabetes, fibromyalgia, or irritable bowel syndrome.
- •pregnant.
- •regularly consume cherries or are allergic to cherries or dairy.
- •currently use anti-inflammatory medications,
- •have used corticosteroids in the last two months.
结局指标
主要结局
Change in c-reactive protein
时间窗: 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
c-reactive protein (mg/L) measured via assay
Change in oxidative capacity
时间窗: 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
oxygen radical absorbance capacity (uM Trolox equivalents) measured via assay
Change in uric acid
时间窗: 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
uric acid (mg/dL) measured via assay
次要结局
未报告次要终点
研究者
Angela Hillman
Assistant Professor
Ohio University