Perioperative Evaluation of Immuno-inflammatory Parameters
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Immune parameters (immunocytes phenotype)
研究概览
简要总结
This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected.
This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.
详细描述
A significant number of published data can be concluded that surgery and anesthetic and analgesic techniques have an impact on immunity and inflammation.
However, none of these studies have been performed with modern techniques, much more reliable evaluation of immune activity, such as the assessment of monocytic degranulation by flow cytometry.
It is therefore important to document immune activity using these new techniques, our patients, perioperative. This will be analyzed, so observational, the potential impact of different therapeutic interventions the patient receives.
This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected.
This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgical patients (and controls)
排除标准
- •Immune disorders
结局指标
主要结局
Immune parameters (immunocytes phenotype)
时间窗: baseline up to 8 days (return to baseline)
Function tests and surface markers
次要结局
- Long term outcome(5 years)
- Coagulation parameters (like platelet function) (substudy)(perioperative period (up to 3 days))
- Inflammatory markers (cytokines) (substudy)(baseline up to 8 days (return to baseline))
研究者
Forget Patrice
Principal Investigator
Université Catholique de Louvain