NCT01719484已完成不适用
Functional Magnetic Resonance Imaging of Stress in Obesity
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- No outcome measures for this study, this is an imaging study only
研究概览
简要总结
To examine the influence of obesity on brain activation during food cue, stress, and neutral relaxing conditions
详细描述
Subjects will participate in an fMRI session to examine changes in frontal and limbic brain regions with food cues, stress and neutral/relaxing imagery
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between ages 18-50 years old.
- •Able to read and write.
- •negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use.
- •WOMEN: have a regular menstrual cycle.
- •BMI: 30 < BMI < 35 for obese subjects (upper limit of 35 selected given our experience with heavier individuals fitting comfortably in the fMRI scanner) and 18.5 < BMI <25 for normal weight subjects (Institute, 2006)
排除标准
- •any major neurological illness or injury and any current or prior clinically significant mental health (including PTSD) or substance use disorder (with exception of nicotine dependence) as determined by SCID interview;
- •Regular use of any psychoactive drugs including anxiolytics and antidepressants.
- •Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded.
- •Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders.
- •Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states).
结局指标
主要结局
No outcome measures for this study, this is an imaging study only
时间窗: Upon study completion
次要结局
未报告次要终点
研究者
研究点 (1)
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