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临床试验/NCT02056821
NCT02056821已完成不适用

Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Henry Ford Health System1 个研究点 分布在 1 个国家目标入组 88 人开始时间: 2014年2月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
88
试验地点
1
主要终点
Change in cerebral blood flow velocities

研究概览

简要总结

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Suspected ischemic stroke within 12 hours of symptom onset
  • NIHSS ≥ 4
  • Age 18 to 90 years

排除标准

  • Baseline modified Rankin Scale > 3
  • Pregnancy
  • Intracranial hemorrhage on head CT
  • Mechanical ventilation prior to enrollment
  • Inadequate temporal windows for TCD analysis

结局指标

主要结局

Change in cerebral blood flow velocities

时间窗: initial 24 hours

Cerebral flow velocities determined by bilateral MCA measurements by TCD

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Joseph Miller, MD

Senior Staff

Henry Ford Health System

研究点 (1)

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