Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.
研究概览
简要总结
This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
详细描述
The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Availability of tumor tissue and patients with thymoma and thymic carcinoma
排除标准
- •NON Availability of tumor tissue and patients with thymoma and thymic carcinoma
结局指标
主要结局
Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.
时间窗: one year
次要结局
- Secondary objective: to correlate the biological characteristics with clinical characteristics and survival data of patients.(one year)