Molecular Analyses of Retinoid-induced Dermatitis in Aged/Photoaged Human Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Retinoid-induced dermatitis
研究概览
简要总结
Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female
- •Subject is at least 21 years of age
- •Good general health
- •No disease states, physical conditions or medications that would impair evaluation of the test sites
- •Willingness and ability to follow protocol
- •Signed written and witnessed informed consent form
- •No use of oral retnoids in the past year
- •No use of topical steroids to the treatment area in the past 2 weeks
排除标准
- •Has received an experimental drug or used and experimental device in the 14 days prior to admission to the study
- •History of keloids
- •History of hypersensitivity to lidocaine or epinephrine
- •Pregnant or nursing women
- •Disease states or physical condition that would impair evaluation of the test sites or compliance with the protocol
- •History of chemical peels or laser treatments to the sites evaluated
结局指标
主要结局
Retinoid-induced dermatitis
时间窗: 6 months
次要结局
未报告次要终点
研究者
Dana L. Sachs, MD
Professor of Dermatology
University of Michigan