A Retrospective Analysis of Outcomes in Outpatients With Major Depressive Disorder (MDD) in a Staff Model HMO: Pharmacogenetic Algorithm for Psychotropic Pharmacotherapeutic Applications
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Number of Outpatient Visits
研究概览
简要总结
Antidepressants are among the most widely prescribed medications, yet only 35-45% of patients achieve remission following an initial antidepressant trial. The financial burden of treatment failures in direct treatment costs, disability, decreased productivity, and missed work may in part derive from a mismatch between optimal, and actual, medications prescribed. The present one year retrospective study seeks to evaluate the indirect and direct healthcare costs for 96 patients with a DSM-IV-TR depressive or anxiety disorder, in relation to an interpretive reporting system designed to predict antidepressant responses based on DNA variations in cytochrome P450 genes (CYP2D6, CYP2C19, CYP1A2), the serotonin transporter gene (SLC6A4), and the serotonin 2A receptor (5HTR2A) genes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major Depressive Disorder
- •Dysthymic Disorder
- •Depressive Disorder NOS
- •Obsessive Compulsive Disorder (OCD)
- •Generalized Anxiety Disorder
- •Panic Disorder
- •Anxiety Disorder NOS
- •Post-Traumatic Stress Disorder (PTSD)
- •Social Phobia
排除标准
- •Bipolar Disorder
- •Schizophrenia
- •Schizoaffective Disorder
- •Previous pharmacogenomic testing
结局指标
主要结局
Number of Outpatient Visits
时间窗: During the one year study window (April 1, 2010 to April 1, 2011)
Number of outpatient healthcare visits during study window
次要结局
- Number of Medical Absence Days(During the one year study window (April 1, 2010 to April 1, 2011))
- Number of Disability Claims(During the one year study window (April 1, 2010 to April 1, 2011))