Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change in level of insulin
研究概览
简要总结
The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).
Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.
Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 years
- •witnessed cardiac arrest
- •interval form emergency call to return of spontaneous circulation 10-45 minutes
排除标准
- •severe pre-arrest disability leading to withdrawing treatment in prehospital phase
- •no concent from next of kin
结局指标
主要结局
Change in level of insulin
时间窗: 60 minutes
Change in level of glucagon
时间窗: 60 minutes
次要结局
- Blood cortisol level(60 minutes after ROSC)
- Blood interleukin-6 level(60 minutes after ROSC)
- Change in level of GLP-1(60 minutes)
- Change in blood glucose level(60 minutes)
研究者
Jouni Nurmi, MD
MD, PhD
Helsinki University Central Hospital