CTRI/2019/04/018511尚未招募未知
Systemic and local oxidative post-translational modification â?? S-glutathionylation in COPD
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Healthy non-smoker
- •Be at least 40 years of age
- •Provide written informed consent
- •Never smoker and not exposed to biomass for >10 years
- •No major abnormality on clinical examination
- •Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry)
- •FEF25-75 > 65%
- •DLCO >= 80% predicted
- •Body plethysmography TLC >= 80% predicted
- •Healthy smoker
- •Be at least 40 years of age
- •Provide written informed consent
- •Be smoking tobacco in the form of bidi or cigarettes for at least 10 pack years
- •No major abnormality on clinical examination
- •Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry)
- •FEF25-75 > 65%
- •DLCO >= 80% predicted
- •Body plethysmography TLC >= 80% predicted
- •Healthy Biomass user
- •Be at least 40 years of age
- •Provide written informed consent
- •Be exposed to biomass for at least 10 fuel-years (women)/ 20 fuel-years (men) (exposure of 2hrs/day for 10 years) after adulthood
- •No major abnormality on clinical examination
- •Normal spirometry, FEV1/FVC >0.70 (or IOS 80-120% predicted if not able to perform Spirometry)
- •FEF25-75 > 65%
- •DLCO >= 80% predicted
- •Body plethysmography TLC >= 80% predicted
- •Tobacco smoking COPD
- •Be at least 40 years of age
- •Provide written informed consent
- •Be smoking tobacco in the form or bidi or cigarettes for at least 10 pack-years
- •Have a clinical diagnosis of COPD (GOLD stage I to III) and post-bronchodilator FEV1/FVC ratio <0.70) (or IOS X > 1500 % predicted if not able to perform Spirometry)
- •DLCO < 80% predicted
- •Body plethysmography TLC < 80% predicted
- •Non-smoking COPD
- •Be at least 40 years of age
- •Provide written informed consent
- •Be exposed to biomass for at least 10 fuel-years (women)/ 20 fuel-years (men) after adulthood
- •Have a clinical diagnosis of COPD (GOLD stage I to III): post-bronchodilator FEV1/FVC ratio <0.70) (or IOS (or IOS X > 1500 % predicted if not able to perform Spirometry))
- •DLCO < 80% predicted
- •Body plethysmography TLC < 80% predicted
- •Never smoker
- •FEV1 reversibility <400 mL to rule out asthma
排除标准
- •Subjects suffering from comorbidities such as diabetes.
- •Very Severe COPD patients would be excluded as the process of sputum induction may worsen their condition
- •History of lung condition other than COPD including respiratory infectious diseases like tuberculosis, asthma, interstitial lung disease, etc
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