Effect of Modified Poco-Poco Exercise to Global DNA Methylation, Growth Differentiation Factor-15, and Sarcopenia Staging in Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Sarcopenia Staging (Skeletal Muscle Index)
研究概览
简要总结
Subject with sarcopenia get modified poco-poco exercise program for 12 weeks
详细描述
34 participants (>60 years) with sarcopenia were modified poco-poco exercises three times weekly for 12 weeks will assessed sarcopenia staging (determined by assessing skeletal muscle index, muscle strength, physical performance) and levels of global DNA methylation and GDF-15.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 60 years old
- •Have sarcopenia (based on AWGSOP 2019 criteria)
排除标准
- •Hearing impairment/loss hindering participants to receive verbal instructions
- •Vision impairment/loss hindering participants to receive instructions
- •Musculoskeletal impairment or severe joint diseases (i.e. deformity in Osteoarthritis or Rheumatoid Arthritis)
- •Participants have been involved in other exercise program
- •Severe cardiovascular disease diagnosed by Cardiologist.
- •Participants will be excluded from the research if they skip 3 sessions of the program consecutively or skip 5 sessions cumulatively
研究组 & 干预措施
Modified poco-poco exercises
Participants performed modified poco-poco exercises three times weekly for 12 weeks and were assessed, including sarcopenia staging (determined by assessing skeletal muscle index, muscle strength, physical performance) and levels of global DNA methylation and GDF-15
干预措施: Modified poco-poco exercises (Procedure)
结局指标
主要结局
Sarcopenia Staging (Skeletal Muscle Index)
时间窗: 12 weeks
Skeletal muscle index
Sarcopenia Staging (Muscle Strength)
时间窗: 12 weeks
Hand Grip Strength, score in kilograms
Sarcopenia Staging (Physical Performance)
时间窗: 12 weeks
Short Physical Performance Battery, score in numerical 0-12
Levels of Global DNA Methylation
时间窗: 12 weeks
Global DNA methylation levels were analyzed using the ELISA-based kit
Levels of Growth Differentiation Factor 15
时间窗: 12 weeks
Growth Differentiation Factor 15 were analyzed the Quantikine ELISA Human GDF-15 Immunoassay
次要结局
未报告次要终点
研究者
Irma Ruslina Defi
Principal Investigator
Universitas Padjadjaran