The neurochemical basis of individual pain sensitivity and pain modulation, Part II, Study 1 - Neurochem2

niversitätsklinikum Essen, Klinik für Neurologie0 个研究点目标入组 70 人开始时间: 2015年11月26日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Signs of renal, cardiovascular, or hepatic disease.
•Signs of raised intraocular pressure.
•Protein-rich diet before study-visit one.
•History of, or present neurologic disorders, e.g. pain disorders, migraine, lower back pain, irritable bowel syndrome, cranial trauma, epilepsia, or sleep disorder.
•History of, or present psychiatric disorder, e.g. depression, schizophrenia, substance abuse, or personality disorders.
•History of, or present severe internal disorders, such as diabetes, neoplasia, thyroid dysfunction, asthma.
•Acute infections (common cold, diarrhea).
•Alcohol consumtion at the day of or the day before study participation.
•Known allergy against any constituent of the study medication.
•Surgery requiring narcosis within the last 6 months.
•Participation in any study requiring the intake of study medication within the last 6 months.
•Any long-term medication, except dietary supplements and hormonal contraception.
•Intake of pain medication (e.g. NSAIDs) within the last 14 days.
•For women: Pregnancy.
•Disorders of the skin that could affect temperature sensation (e.g. neurodermitis).
•Abnormal pain- or temperature sensitivity at the forearm, defined as :
•o Heat pain threshold > 50°C.
•o Warmth detection threshold >37°C.
•o Unstable heat pain ratings Unzuverlässige Differenzierung von Hitzereizen or VAS40<44.0°C oder VAS80>48.5°C.

发起方

niversitätsklinikum Essen, Klinik für Neurologie